![Targeting the Kappa Opioid Receptor to Reduce Drug Use and Relapse | National Institute on Drug Abuse (NIDA) Targeting the Kappa Opioid Receptor to Reduce Drug Use and Relapse | National Institute on Drug Abuse (NIDA)](https://nida.nih.gov/sites/default/files/styles/content_image_medium/public/images/valenza_zamarripa_promo.jpg?itok=HRbtRBEw)
Targeting the Kappa Opioid Receptor to Reduce Drug Use and Relapse | National Institute on Drug Abuse (NIDA)
![Dopaminergic cellular and circuit contributions to kappa opioid receptor mediated aversion | Semantic Scholar Dopaminergic cellular and circuit contributions to kappa opioid receptor mediated aversion | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/4d3293c2088da60abdac11b52d2ea3b4ecc4f433/11-Figure2-1.png)
Dopaminergic cellular and circuit contributions to kappa opioid receptor mediated aversion | Semantic Scholar
![Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis - ScienceDirect Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0028390820304093-fx1.jpg)
Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis - ScienceDirect
![The blocking of kappa‐opioid receptor reverses the changes in dorsolateral striatum dopamine dynamics during the amphetamine sensitization - Azocar - 2019 - Journal of Neurochemistry - Wiley Online Library The blocking of kappa‐opioid receptor reverses the changes in dorsolateral striatum dopamine dynamics during the amphetamine sensitization - Azocar - 2019 - Journal of Neurochemistry - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/d47b6fb7-e8b2-4af5-af57-9392445d2faf/jnc14612-fig-0005-m.png)
The blocking of kappa‐opioid receptor reverses the changes in dorsolateral striatum dopamine dynamics during the amphetamine sensitization - Azocar - 2019 - Journal of Neurochemistry - Wiley Online Library
![Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment - ScienceDirect Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0278584615000020-fx1.jpg)
Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment - ScienceDirect
![Down-regulation of kappa opioid receptor promotes ESCC proliferation, invasion and metastasis via the PDK1-AKT signaling pathway | Cell Communication and Signaling | Full Text Down-regulation of kappa opioid receptor promotes ESCC proliferation, invasion and metastasis via the PDK1-AKT signaling pathway | Cell Communication and Signaling | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs12964-022-00833-3/MediaObjects/12964_2022_833_Figa_HTML.png)
Down-regulation of kappa opioid receptor promotes ESCC proliferation, invasion and metastasis via the PDK1-AKT signaling pathway | Cell Communication and Signaling | Full Text
![Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation | Scientific Reports Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation | Scientific Reports](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41598-021-88118-6/MediaObjects/41598_2021_88118_Fig7_HTML.png)
Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation | Scientific Reports
![Neurophysiological process - Kappa-type opioid receptor in transmission of nerve impulses Pathway Map - PrimePCR | Life Science | Bio-Rad Neurophysiological process - Kappa-type opioid receptor in transmission of nerve impulses Pathway Map - PrimePCR | Life Science | Bio-Rad](https://commerce.bio-rad.com/webroot/web/images/lsr/global/english/products/amplification_pcr/primepcr/pathway/zoom_out/2551_map.png)
Neurophysiological process - Kappa-type opioid receptor in transmission of nerve impulses Pathway Map - PrimePCR | Life Science | Bio-Rad
![IJMS | Free Full-Text | Distinct Effects of Nalmefene on Dopamine Uptake Rates and Kappa Opioid Receptor Activity in the Nucleus Accumbens Following Chronic Intermittent Ethanol Exposure IJMS | Free Full-Text | Distinct Effects of Nalmefene on Dopamine Uptake Rates and Kappa Opioid Receptor Activity in the Nucleus Accumbens Following Chronic Intermittent Ethanol Exposure](https://pub.mdpi-res.com/ijms/ijms-17-01216/article_deploy/html/images/ijms-17-01216-ag-1024.png?1472182150)
IJMS | Free Full-Text | Distinct Effects of Nalmefene on Dopamine Uptake Rates and Kappa Opioid Receptor Activity in the Nucleus Accumbens Following Chronic Intermittent Ethanol Exposure
![The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology of Schizophrenia: A Review of the Evidence - ScienceDirect The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology of Schizophrenia: A Review of the Evidence - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0006322319313794-gr1.jpg)
The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology of Schizophrenia: A Review of the Evidence - ScienceDirect
![Kappa Opioid Receptor Structure Revealed, A Potential Milestone in Medication Development – Maine Suboxone Treatment Kappa Opioid Receptor Structure Revealed, A Potential Milestone in Medication Development – Maine Suboxone Treatment](https://d14rmgtrwzf5a.cloudfront.net/sites/default/files/che-image-web.jpg)
Kappa Opioid Receptor Structure Revealed, A Potential Milestone in Medication Development – Maine Suboxone Treatment
![Activation of opioid receptors in the enteric nervous system. MOR mu... | Download Scientific Diagram Activation of opioid receptors in the enteric nervous system. MOR mu... | Download Scientific Diagram](https://www.researchgate.net/publication/355537946/figure/fig1/AS:1082947297902592@1635206164135/Activation-of-opioid-receptors-in-the-enteric-nervous-system-MOR-mu-opioid-receptor-DOR.png)
Activation of opioid receptors in the enteric nervous system. MOR mu... | Download Scientific Diagram
![Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists](https://www.frontiersin.org/files/Articles/447554/fphar-10-00407-HTML/image_m/fphar-10-00407-g001.jpg)
Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists
![Table II from Systemic kappa opioid receptor agonists in the treatment of chronic pruritus: a literature review. | Semantic Scholar Table II from Systemic kappa opioid receptor agonists in the treatment of chronic pruritus: a literature review. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/067b22436f475a7fe6209c314a4fa942dd154a0f/3-TableII-1.png)
Table II from Systemic kappa opioid receptor agonists in the treatment of chronic pruritus: a literature review. | Semantic Scholar
![Molecules | Free Full-Text | Design of κ-Opioid Receptor Agonists for the Development of Potential Treatments of Pain with Reduced Side Effects Molecules | Free Full-Text | Design of κ-Opioid Receptor Agonists for the Development of Potential Treatments of Pain with Reduced Side Effects](https://www.mdpi.com/molecules/molecules-28-00346/article_deploy/html/images/molecules-28-00346-g007.png)